Time that remains

Endometriosis: A Disease That Remains Enigmatic

Endometriosis, a gynecologic pathology, is defined by the presence of a tissue similar to uterine endometrium, which is located in places other than physiologically appropriate. These endometrial heterotopic islets contain glands and stroma and are functionally capable of responding to exogenous, endogenous, or local hormonal stimuli. Endometriosis affects 8%-10% of women of reproductive age; i...

The time that remains: organ donation, temporal duration, and Bildung in Kazuo Ishiguro's Never let me go.

One more time: bibliometric analysis of scientific output remains complicated

Dear Sir, In the May issue of the Netherlands Heart Journal, we published an update [1] of a previous bibliometric analysis of the scientific work of Dutch professors in clinical cardiology [2]. The paper was accompanied by an editorial [3] in the same issue and another one in the subsequent June issue [4]. Van der Wall [3] summarises our paper and emphasises that we have stated ‘....that citat...

Evidence that blood pressure remains under the control of arterial baroreceptors in renal hypertensive rats.

The purpose of the present study was to determine the range of the influence of the baroreflex on blood pressure in chronic renal hypertensive rats. Supramaximal electrical stimulation of the aortic depressor nerve and section of the baroreceptor nerves (sinoaortic denervation) were used to obtain a global analysis of the baroreceptor-sympathetic reflex in normotensive control and in chronic (2...

Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

Abiraterone acetate is a potent, selective, and orally bioavailable small molecule inhibitor of CYP17, an enzyme that catalyzes two key serial reactions (17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis. Clinical trials have confirmed that specific inhibition of CYP17 is safe and results in clinically important antitumor activity in up to 70% of castrate patients with...